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Amphetamine is thought to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit several P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes point out small inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by a number